Ms. Frizzle and her class along with an inventive high-tech bus that invites children on high-flying hijinks that introduce the incredible world of science.

When Carole Baskin, a big cat enthusiast, learns that when fellow exotic animal lover Joe "Exotic" Schreibvogel is breeding and using his big cats for profit, she sets out to shut down his venture, inciting a quickly escalating rivalry. But Carole has a checkered past of her own and when the claws come out, Joe will stop at nothing to expose what he sees as her hypocrisy.